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KMID : 0545120070170030543
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 3 p.543 ~ p.545
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Synthesis and Biological Activity of Fungal Metabolite, 4-Hydroxy-3-(3’-Methyl-2’-Butenyl)-Benzoic Acid
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Kim Hye-Jin
Kwon Ho-Jeong
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Abstract
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4-Hydroxy-3-(3’-methyl-2’-butenyl)-benzoic acid (HMBA) was previously isolated from Curvularia sp. KF119 as a cell-cycle inhibitor. However, the present study used a novel and practical synthetic method to prepare a large quantity of HMBA. The synthetic HMBA was found to inhibit the cell-cycle progression of HeLa cells with a comparable potency to the natural fungal metabolite. The inhibition of the cell-cycle progression by the synthetic HMBA involved both the activation of p21WAF1 and the inhibition of cyclin D1 expression in the cells. Consequently, this new synthetic procedure provides an easy and convenient way to produce or manipulate the original fungal metabolite
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KEYWORD
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Fungal metabolite, HMBA, cell-cycle inhibition, synthesis of natural product
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